Trifluoroacetic acid → HCID 53855375, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 20-13 (0.031 g, 0.052 mmol) in dichloromethane (10 mL) was added TFA (1 mL). The solution was stirred for 16 hours at 85° C. after which the solvent was removed in vacuo and azeotroped twice with toluene (15 mL). The residue was chromatographed (silica gel, 15:10:1:1 followed by 10:10:1:1 ethyl acetate/EtOH/water/NH4OH) to give 20-14 as a white solid.

Provenance & Evidence