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Sodium Hydroxide → Sodium 2-(2,1,3-benzothiadiazol-5-yl)-3-benzyl-4-(4-methoxyphenyl)-4-oxo-2-butenoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 3-(2,1,3-Benzothiadiazol-5-yl)-4-benzyl-5-hydroxy-5-(4-methoxy-phenyl)-5H-furan-2-one | HCID 15410455 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | Sodium 2-(2,1,3-benzothiadiazol-5-yl)-3-benzyl-4-(4-methoxyphenyl)-4-oxo-2-butenoate | HCID 74088571 | — |
反応手順
0.7 ml of 0.1 N NaOH is added to a suspension of 30 mg of 3-(2,1,3-benzothiadiazol-5-yl)-4-benzyl-5-hydroxy-5-(4-methoxyphenyl)-5H-furan-2-one in 1 ml of methanol and the mixture is stirred at room temperature. The solvent is removed, the residue is partitioned between water and diethyl ether, and the agueous phase is then lyophilized. Sodium 2-(2,1,3-benzothiadiazol-5-yl)-3-benzyl-4-(4-methoxyphenyl)-4-oxo-2-butenoate, FAB 453, is obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06017939 |
| 出典データセット | uspto-grants-2000_01 |
| ORD ID | ord-c1971befad4846e1872dd28a073ccee5 |
| 出典メモ | uspto-grants-2000_01 |