反应详情

1-Benzenesulfonyl-5-bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine (378 mg, 1.076 mmole) and 4-((4-methylpiperazin-1-yl)methyl)phenylboronic acid (303 mg, 1.29 mmole) are dissolved in acetonitrile (10 mL) and treated with 10 mL 1 M sodium carbonate solution. To this is added 40 mg of PdCl2(PPh3)2 catalyst, and the mixture is irradiated for 5 minutes at 150 degrees in a Biotage microwave reactor. After cooling, the reaction mixture is diluted with water and extracted with ethyl acetate, dried, and concentrated. MPLC silica gel chromotagraphy 5-20% MeOH in dichloromethane gradient elution, provided 367 mg of the title compound as a solid.

1. customthe mixture is irradiated for 5 minutes at 150 degrees in a Biotage microwave reactor
2. temperatureAfter cooling
3. extractionextracted with ethyl acetate
4. customdried
5. concentrationconcentrated
6. washMPLC silica gel chromotagraphy 5-20% MeOH in dichloromethane gradient elution