Methanol → HCID 19364895, compound

HRID 850761Notes

Reaction equation

HRID 850761 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]3[CH:18]=[C:17]([CH3:19])[C:16](=[O:20])[C:8]4[CH:9]=[C:10]([OH:15])[CH:11]=[C:12]([C:13]=2[CH:14]=1)[C:7]3=4.[C:21](OC(=O)C)(=[O:23])[CH3:22].CO>N1C=CC=CC=1>[C:21]([O:15][C:10]1[CH:11]=[C:12]2[C:7]3=[C:8]([C:16](=[O:20])[C:17]([CH3:19])=[CH:18][N:6]3[C:5]3[CH:4]=[CH:3][C:2]([Br:1])=[CH:14][C:13]2=3)[CH:9]=1)(=[O:23])[CH3:22]

Participants

5

Reactant 3

HCID 887MethanolHCID 7918Acetic AnhydrideHCID 2125284210-bromo-2-hydroxy-5-methyl-4H-pyrido [3,2,1-jk]carbazole-4-one

Product 1

HCID 19364895HCID 19364895, compoundYield 70%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

10-bromo-2-hydroxy-5-methyl-4H-pyrido[3,2,1-jk]carbazole-4-one (200 mg) obtained in Example 49 was suspended in pyridine (6 ml), and acetic anhydride (0.18 ml) was added to the suspension. The mixture was stirred at room temperature for 40 minutes and a small amount of methanol was added dropwise to the reaction mixture. The solvent was evaporated under reduced pressure, and the residue was washed with ethanol and ether in succession to obtain the title compound (160 mg, 70%).

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. washthe residue was washed with ethanol and ether in succession

Sources & evidence

ORD record
ord-74ec35335de04b0c93c23021cab90a9b
Source dataset
uspto-grants-2000_01
Patent number
US06018046

Reaction notes

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