Sodium Hydroxide → HCID 19364879, compound

HRID 850770Notes

Reaction equation

HRID 850770 reaction equation
C([O:4][CH2:5][C:6]1[CH:7]=[C:8]([CH2:12][O:13][C:14]2[CH:15]=[C:16]3[C:24]4=[C:25]([C:27](=[O:30])[CH:28]=[CH:29][N:23]4[C:22]4[CH:21]=[CH:20][C:19]([Br:31])=[CH:18][C:17]3=4)[CH:26]=2)[CH:9]=[N:10][CH:11]=1)(=O)C.[OH-].[Na+]>CO.O>[Br:31][C:19]1[CH:20]=[CH:21][C:22]2[N:23]3[CH:29]=[CH:28][C:27](=[O:30])[C:25]4[CH:26]=[C:14]([O:13][CH2:12][C:8]5[CH:9]=[N:10][CH:11]=[C:6]([CH2:5][OH:4])[CH:7]=5)[CH:15]=[C:16]([C:17]=2[CH:18]=1)[C:24]3=4

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 19364884HCID 19364884, compound

Product 1

HCID 19364879HCID 19364879, compoundYield 93.2%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

2-(5-acetoxymethyl-3-pyridylmethyloxy)-10-bromo-4H-pyrido[3,2,1-jk]carbazole-4-one (200 mg) obtained in Example 69 was suspended in methanol (12 ml), and a solution of sodium hydroxide (100 mg) in water (0.8 ml) was added to the suspension. The mixture was stirred at room temperature for 1 hour, and the precipitated crystals were washed with methanol and ether in succession, and recovered by filtration to obtain the title compound (170 mg, 93%).

Workup

  1. washthe precipitated crystals were washed with methanol and ether in succession
  2. filtrationrecovered by filtration

Sources & evidence

ORD record
ord-dc4675ce7a8c4cae8844ed4f121e0c1e
Source dataset
uspto-grants-2000_01
Patent number
US06018046

Reaction notes

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