Ethanol → HCID 19364888, compound

HRID 850776Notes

Reaction equation

HRID 850776 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]3[CH:18]=[C:17]([CH2:19][N:20]4[CH:24]=[N:23][CH:22]=[N:21]4)[C:16](=[O:25])[C:8]4[CH:9]=[C:10]([OH:15])[CH:11]=[C:12]([C:13]=2[CH:14]=1)[C:7]3=4.[C:26](OC(=O)C)(=[O:28])[CH3:27].C(O)C>N1C=CC=CC=1>[C:26]([O:15][C:10]1[CH:11]=[C:12]2[C:7]3=[C:8]([C:16](=[O:25])[C:17]([CH2:19][N:20]4[CH:24]=[N:23][CH:22]=[N:21]4)=[CH:18][N:6]3[C:5]3[CH:4]=[CH:3][C:2]([Br:1])=[CH:14][C:13]2=3)[CH:9]=1)(=[O:28])[CH3:27]

Participants

5

Reactant 3

HCID 702EthanolHCID 7918Acetic AnhydrideHCID 19364920HCID 19364920, compound

Product 1

HCID 19364888HCID 19364888, compoundYield 72%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

10-bromo-2-hydroxy-5-(1H-1,2,4-triazole-1-ylmethyl)-4H-pyrido[3,2,1-jk]carbazole-4-one (30 mg) obtained in Example 96 was suspended in pyridine (0.8 ml), and acetic anhydride (0.021 ml) was added, and the mixture was stirred at room temperature for 3 hours. After adding dropwise a small amount of ethanol to the reaction mixture, the solvent was evaporated under reduced pressure. The residue was washed with ethanol and ether in succession to obtain the title compound (24 mg, 72%).

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. washThe residue was washed with ethanol and ether in succession

Sources & evidence

ORD record
ord-c7fdcf360305455faee8e04c3634ee32
Source dataset
uspto-grants-2000_01
Patent number
US06018046

Reaction notes

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