Boron tribromide → HCID 21252859, compound

Participants

Reaction Steps

9-bromo-2-methoxy-5-methyl-4H-pyrido[3,2,1-jk]carbazole-4-one (1.6 g) produced in Example 113 was suspended in anhydrous methylene chloride (120 ml), and a solution of boron tribromide in methylene chloride (1M, 28 ml) was added dropwise at room temperature. After stirring at room temperature for 3 hours, the reaction mixture was poured into ice water (100 ml) and the crystals precipitated were recovered by filtration. The thus obtained crude crystals were washed with ethanol and ether in succession to obtain the title compound (1.5 g, 98%).

Provenance & Evidence