Butyryl chloride → HCID 19364933, compound

HRID 850805Notes

Reaction equation

HRID 850805 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]3[CH:18]=[C:17]([CH2:19][C:20]4[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=4)[C:16](=[O:26])[C:8]4[CH:9]=[C:10]([OH:15])[CH:11]=[C:12]([C:13]=2[CH:14]=1)[C:7]3=4.[CH3:27][CH2:28][CH2:29][C:30](Cl)=[O:31]>N1C=CC=CC=1>[C:30]([O:15][C:10]1[CH:11]=[C:12]2[C:7]3=[C:8]([C:16](=[O:26])[C:17]([CH2:19][C:20]4[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=4)=[CH:18][N:6]3[C:5]3[CH:4]=[CH:3][C:2]([F:1])=[CH:14][C:13]2=3)[CH:9]=1)(=[O:31])[CH2:29][CH2:28][CH3:27]

Participants

4

Reactant 2

HCID 8855Butyryl chlorideHCID 19364896HCID 19364896, compound

Product 1

HCID 19364933HCID 19364933, compoundYield 70%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

10-fluoro-2-hydroxy-5-(3-pyridylmethyl)-4H-pyrido[3,2,1-jk]carbazole-4-one (150 mg) produced in Example 236 was suspended in pyridine (12 ml), and n-butyryl chloride (74 μl) was added dropwise to the suspension in an ice bath. After stirring for 50 minutes, the solvent was evaporated under reduced pressure. The residue was washed with ether to obtain the title compound (126 mg, 70%).

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. washThe residue was washed with ether

Sources & evidence

ORD record
ord-76e980cf56964bd186387e6854f76f63
Source dataset
uspto-grants-2000_01
Patent number
US06018046

Reaction notes

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