Hydrochloric Acid → HCID 178483317, compound

Participants

Reaction Steps

A reaction mixture was prepared from 1.16 g of 2-(2-dimethylaminomethyl-4-thiazolylmethylthio)ethylamine, 0.45 g of sodium dicyanamide, 4.8 ml 1N aqueous hydrochloric acid and 8 ml of n-butanol. The reaction mixture was heated to reflux temperature for about 16 hours and then was filtered. Evaporation of the filtrate to dryness yielded a residue which was purified by chromatography over silica using a 98:2 ethyl acetate:methanol solvent mixture as the eluant. Fractions shown by tlc to contain the desired product were combined and the solvent evaporated therefrom. N-2-(2-dimethylaminomethyl-4-thiazolylmethylthio)ethyl-N'-cyanoguanidine thus obtained was a glass.

Provenance & Evidence