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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 850953Generated: October 27, 2026

1,3,4-Thiadiazol-2-amine → 2-(N-benzyloxycarbonyl-DL-isoleucylamino)-1,3,4-thiadiazole

https://huagongshe.com/reaction/850953

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,3,4-Thiadiazol-2-amineHCID 19909—
ReactantN-benzyloxycarbonyl-L-isoleucineHCID 102945—
Product2-(N-benzyloxycarbonyl-DL-isoleucylamino)-1,3,4-thiadiazoleHCID 1314551056.6%

Reaction Steps

26.5 g of N-benzyloxycarbonyl-DL-isoleucine and 10 g of 2-amino-1,3,4-thiadiazole were reacted in the same manner as in Example 3(i) to obtain 19.5 g (yield: 56%) of 2-(N-benzyloxycarbonyl-DL-isoleucylamino)-1,3,4-thiadiazole as white crystals having a melting point of 149° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04382142
Source datasetuspto-grants-1983_05
ORD IDord-867032a5d88647ba8c89db7026dadd3d
Source noteuspto-grants-1983_05