HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 2-(t-butoxycarbonyl-DL-threonyl)amino-1,3,4-thiadiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Ethyl chloroformate | HCID 10928 | — |
| Reactant | 1,3,4-Thiadiazol-2-amine | HCID 19909 | — |
| Reactant | N-(tert-butyloxycarbonyl)-L-threonine | HCID 100116 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-(t-butoxycarbonyl-DL-threonyl)amino-1,3,4-thiadiazole | HCID 13037994 | 79.3% |
Reaction Steps
Using the same procedure as in Example 1(i), 10 g of N-t-butoxycarbonyl-DL-threonine, 4.6 g of triethylamine, 5.0 g of ethyl chlorocarbonate and 4.6 g of 2-amino-1,3,4-thiadiazole were reacted in 150 ml of tetrahydrofuran to obtain 10.9 g (yield: 79%) of 2-(N-t-butoxycarbonyl-DL-threonylamino)-1,3,4-thiadiazole as white powder having a melting point of 165°-170° C. (dec.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04382142 |
| Source dataset | uspto-grants-1983_05 |
| ORD ID | ord-0e4d050e314c4009949019768a05d614 |
| Source note | uspto-grants-1983_05 |