反应详情

A mixture of 6.9 g. of 4-hexadecylamino-2-cyanothiophene, 80 ml. of methyl cellosolve, and 80 ml. of 1 N sodium hydroxide is refluxed for 21 hours. After cooling in an ice bath, the solid is filtered and thoroughly washed with methylene chloride. The solid is then added to 100 ml. of water and 5 ml. of concentrated hydrochloric acid and stirred for 8 hours. The solid is filtered and recrystallized from isopropanol.

1. additionA mixture of 6.9 g
2. temperatureAfter cooling in an ice bath
3. filtrationthe solid is filtered
4. washthoroughly washed with methylene chloride
5. additionThe solid is then added to 100 ml
6. filtrationThe solid is filtered
7. customrecrystallized from isopropanol