Hydrochloric Acid → Ethyl 5-hexadecylamino-2-thiophenecarboxylate

HRID 850966Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 850966
[C:1]([NH:18][C:19]1[S:23][C:22]([C:24]([O:26][CH2:27][CH3:28])=[O:25])=[CH:21][CH:20]=1)(=O)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].B.Cl>O1CCCC1>[CH2:1]([NH:18][C:19]1[S:23][C:22]([C:24]([O:26][CH2:27][CH3:28])=[O:25])=[CH:21][CH:20]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 6331BoraneHCID 20503665Ethyl 5-hexadecanamido-2-thiophenecarboxylate

Produkt 1

HCID 20503573Ethyl 5-hexadecylamino-2-thiophenecarboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To 1.1 g. of ethyl 5-hexadecanamido-2-thiophenecarboxylate is added 5 ml. 1 M borane in tetrahydrofuran. The reaction mixture is refluxed for 1 hour. After cooling, the reaction mixture is poured into 50 ml. of 1 N hydrochloric acid. The solid is collected and then recrystallized from both carbon tetrachloride and ethanol to yield the product.

Aufarbeitung

  1. temperatureThe reaction mixture is refluxed for 1 hour
  2. temperatureAfter cooling
  3. additionthe reaction mixture is poured into 50 ml
  4. customThe solid is collected
  5. customrecrystallized from both carbon tetrachloride and ethanol
  6. customto yield the product

Quellen und Nachweise

ORD-Eintrag
ord-b0c71eb6432b45e7abd1974cb4f6e5b2
Quelldatensatz
uspto-grants-1983_05
Patentnummer
US04382143

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