HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hexadecylamine → Ethyl 2-hexadecylamino-5-pyrimidinecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hexadecylamine | HCID 8926 | — |
| Reactant | Hexamethylphosphoramide | HCID 12679 | — |
| Reactant | Ethyl 2-(methylthio)pyrimidine-5-carboxylate | HCID 10442716 | — |
| Solvent | Water | HCID 962 | — |
| Product | Ethyl 2-hexadecylamino-5-pyrimidinecarboxylate | HCID 20503635 | — |
Reaction Steps
A mixture of 2.0 g of ethyl 2-methylthio-5-pyrimidinecarboxylate, 3.0 g. of hexadecylamine, and 20 ml. of hexamethylphosphoramide is heated at 110° C. for 10 hours, allowed to cool, and diluted with water. Filtration affords a solid which is crystallized from hexane to yield ethyl 2-hexadecylamino-5-pyrimidinecarboxylate as a tan solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04382143 |
| Source dataset | uspto-grants-1983_05 |
| ORD ID | ord-985a279069fe4e5aa1e33147ff8edd81 |
| Source note | uspto-grants-1983_05 |