HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hexadecylamine → Methyl 6-hexadecylamino-3-pyridinecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hexadecylamine | HCID 8926 | — |
| Reactant | Hexamethylphosphoramide | HCID 12679 | — |
| Reactant | Methyl 6-chloropyridine-3-carboxylate | HCID 254249 | — |
| Solvent | Water | HCID 962 | — |
| Product | Methyl 6-hexadecylamino-3-pyridinecarboxylate | HCID 20503576 | — |
Reaction Steps
A mixture of 5.13 g. of methyl 6-chloronicotinate, 7.23 g. of hexadecylamine and 150 ml. of hexamethylphosphoramide is stirred at 130° for 6 hours. Cooling and dilution with water affords a precipitate which is collected by filtration and recrystallized from ethyl acetate and then from acetone to yield methyl 6-hexadecylamino-3-pyridinecarboxylate as a tan solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04382143 |
| Source dataset | uspto-grants-1983_05 |
| ORD ID | ord-7f9c119ebae74df0aa104b0070b383ea |
| Source note | uspto-grants-1983_05 |