Sodium Hydroxide → HCID 20503647, compound

HRID 850988Notes

Reaction equation

HRID 850988 reaction equation
[CH2:1]([NH:17][C:18]1[CH:19]=[C:20]([C:23]([NH:25][CH2:26][C:27]([O:29]CC)=[O:28])=[O:24])[S:21][CH:22]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].[OH-].[Na+]>C(O)C>[CH2:1]([NH:17][C:18]1[CH:19]=[C:20]([C:23]([NH:25][CH2:26][C:27]([OH:29])=[O:28])=[O:24])[S:21][CH:22]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 20503624HCID 20503624, compound

Product 1

HCID 20503647HCID 20503647, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 26 g. of ethyl N-(4-hexadecylamino-2-thiophenecarbonyl)glycinate, 110 ml. of 1 N sodium hydroxide solution; and 100 ml. of ethanol is stirred at ambient temperature for 2 hours and then partially evaporated. The aqueous solution is washed with diethyl ether, acidified with 6 N hydrochloric acid, and filtered. The white solid is dried in vacuo and recrystallized from acetone to yield the product as a white solid.

Workup

  1. additionA mixture of 26 g
  2. custompartially evaporated
  3. washThe aqueous solution is washed with diethyl ether
  4. filtrationfiltered
  5. customThe white solid is dried in vacuo
  6. customrecrystallized from acetone

Sources & evidence

ORD record
ord-3141abf7b8194f33929525efd0a31e8d
Source dataset
uspto-grants-1983_05
Patent number
US04382143

Reaction notes

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