反应详情

A solution of 25 g. of 4-hexadecylamino-2-thiophenecarbonyl chloride hydrochloride and 5.6 g. of methanesulfonamide in 250 ml. of pyridine is stirred under reflux for 2 hours and then concentrated in vacuo. The residue is partitioned between water and diethyl ether; the aqueous layer acidified with 1 N hydrochloric acid and the organic layer seperated, dried over magnesium sulfate, and evaporated. Crystallization of the residual white solid from 60% aqueous acetic acid and then from methylene chloride-hexane affords the product as a white solid.

1. temperatureunder reflux for 2 hours
2. concentrationconcentrated in vacuo
3. customThe residue is partitioned between water and diethyl ether
4. customthe organic layer seperated
5. dry with materialdried over magnesium sulfate
6. customevaporated
7. customCrystallization of the residual white solid from 60% aqueous acetic acid