Acetonitrile → HCID 86738857, compound

Participants

Reaction Steps

A mixture of the above 6-[[[1-acetyl-4-(1-methoxy-1-methylethoxy)2-pyrrolidinyl]carbonyl]amino]-1,2-dihydro-2-oxo-3-quinolinecarboxylic acid, 75 ml of acetonitrile, 5 ml of dimethylformamide, and 3.47 g (24.4 mmol) carbonyldiimidazole is heated at 42°-50° for 2/3 hours and is stirred for 2 hours at room temperature. The mixture is cooled with ice and stirred overnight at room temperature. The solution is concentrated to an oil and treated with tetrahydrofuran and ether, and the solid filtered to give 1.70 g of 6-[[[1-acetyl-4-(1-methoxy-1-methylethoxy)-2-pyrrolidinyl]carbonyl]amino]-1,2-dihydro-2-oxo-3-quinolinecarboxylic acid imidazolide.

Provenance & Evidence