反应详情

To a stirred solution of benzyl 2-(3-(trifluoromethyl)phenyl)-1H-benzo[d]imidazol-4-ylcarbamate (12; 1.45 g, 3.5 mmol) in methanol (20 mL) was added 5% Pd/C (0.20 g). The reaction mixture was thoroughly purged with nitrogen and then stirred under 1 atm of hydrogen at room temperature for 18 h. The mixture was filtered through a pad of Celite and the filtrate was concentrated under reduced pressure to give 2-(3-(trifluoromethyl)phenyl)-1H-benzo[d]imidazol-4-amine 13 (0.90 g, 3.25 mmol, 93%) as a solid. MS (ESI) calcd for C14H10F3N3: 277.08; found: 278 [M+H].

1. customThe reaction mixture was thoroughly purged with nitrogen
2. filtrationThe mixture was filtered through a pad of Celite
3. concentrationthe filtrate was concentrated under reduced pressure