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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 851099Generated: October 30, 2026

3-(Dimethylamino)pyrrolidine → 7-(3-Dimethylamino-1-pyrrolidinyl)-6-fluoro-1-(2-fluoroethyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid

https://huagongshe.com/reaction/851099

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(Dimethylamino)pyrrolidineHCID 2758519—
ReactantEthyl 7-ethylsulfonyl-6-fluoro-1-(2-fluoroethyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylateHCID 13135049—
Product7-(3-Dimethylamino-1-pyrrolidinyl)-6-fluoro-1-(2-fluoroethyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acidHCID 13135055—

Reaction Steps

The same reaction as in Example 4 was carried out using ethyl 7-ethylsulfonyl-6-fluoro-1-(2-fluoroethyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate and 3-dimethylaminopyrrolidine as starting materials. There was obtained the compound 5, m.p. 247°-249° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04382937
Source datasetuspto-grants-1983_05
ORD IDord-4e9bf275d4314a2c8ec625d4388cf682
Source noteuspto-grants-1983_05