反应详情

A solution of methyl 5-(chloromethyl)-3-thiophene-carboxylate (1.9 g) in dry diethylether (100 ml) was treated with anhydrous dimethylamine (5 ml). After 6 hours the solvent was removed in vacuo and the residue was dissolved in 5 M hydrochloric acid (20 ml). The aqueous solution was washed with diethylether, basified with 5 M sodium hydroxide (30 ml) and extracted with ether. The ethereal extracts were evaporated to give an oily residue which was distilled to yield the title compound as a colourless oil (1.6 g) b.p. 120°-130°/0.5 mm.

1. customAfter 6 hours the solvent was removed in vacuo
2. dissolutionthe residue was dissolved in 5 M hydrochloric acid (20 ml)
3. washThe aqueous solution was washed with diethylether
4. extractionextracted with ether
5. customThe ethereal extracts were evaporated
6. customto give an oily residue which
7. distillationwas distilled