Sodium Carbonate → HCID 88649613, compound

HRID 851112Notes

Reaction equation

HRID 851112 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[S:9][CH:8]=[C:7]([O:10][CH2:11][CH2:12][CH2:13][OH:14])[CH:6]=1)[CH3:3].[CH3:15][S:16]([Cl:19])(=[O:18])=[O:17].C(=O)([O-])[O-].[Na+].[Na+]>ClCCl>[ClH:19].[CH3:15][S:16]([O:14][CH2:13][CH2:12][CH2:11][O:10][C:7]1[CH:6]=[C:5]([CH2:4][N:2]([CH3:3])[CH3:1])[S:9][CH:8]=1)(=[O:18])=[O:17]

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 31297Methanesulfonyl chlorideHCID 12926523HCID 12926523, compound

Product 1

HCID 88649613HCID 88649613, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 3-[5-(dimethylaminomethyl)-3-thienyloxy]-1-propanol (0.25 g) and methanesulphonyl chloride (0.1 ml) in dry dichloromethane (10 ml) at 0°-5° was stirred for 1 h. The mixture was poured onto an ice cold 4% aqueous solution of sodium carbonate (50 ml). The solution was extracted with dichloromethane (20 ml). The organic extract was evaporated to give the title compound (0.05 g) as a white solid.

Workup

  1. extractionThe solution was extracted with dichloromethane (20 ml)
  2. extractionThe organic extract
  3. customwas evaporated

Sources & evidence

ORD record
ord-39e50d0883ff477d95d376a0f1f48e80
Source dataset
uspto-grants-1983_05
Patent number
US04382929

Reaction notes

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