Hydrochloric Acid → HCID 86738859, compound

Participants

Reaction Steps

A mixture of 1-[3-(4-benzhydryl-1-piperazinyl)propyl]isatin (1.81 g) and O-methylhydroxylamine hydrochloride (420 mg) in methanol (36 ml) was stirred for an hour at ambient temperature. After addition of 29% ethanolic hydrogen chloride (2 ml), the reaction mixture was evaporated to dryness. The residue was triturated with ethanol and then recrystallized from 90% ethanol to give pale yellow crystals of 1-[3-(4-benzhydryl-1-piperazinyl)propyl]-3-methoxyimino-2-indolinone dihydrochloride (1.65 g), mp. 191° to 196° C.

Provenance & Evidence