Ethyl chloroformate → Ethyl 3-(3-methoxyphenyl)-1,2,5,6-tetrahydro-1-pyridine-carboxylate

HRID 851135Notes

Reaction equation

HRID 851135 reaction equation
C([N:8]1[CH2:13][CH2:12][CH:11]=[C:10]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([O:20][CH3:21])[CH:15]=2)[CH2:9]1)C1C=CC=CC=1.Cl[C:23]([O:25][CH2:26][CH3:27])=[O:24]>C1C=CC=CC=1>[CH3:21][O:20][C:16]1[CH:15]=[C:14]([C:10]2[CH2:9][N:8]([C:23]([O:25][CH2:26][CH3:27])=[O:24])[CH2:13][CH2:12][CH:11]=2)[CH:19]=[CH:18][CH:17]=1

Participants

4

Reactant 2

HCID 10928Ethyl chloroformateHCID 151054501-Benzyl-3-(3-methoxyphenyl)-1,2,5,6-tetrahydropyridine

Product 1

HCID 20502638Ethyl 3-(3-methoxyphenyl)-1,2,5,6-tetrahydro-1-pyridine-carboxylate

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

A solution of 11.4 g of the product of Step B, 25 ml of benzene and 5.9 ml of ethyl chloroformate was refluxed for 3 hours and was then evaporated to dryness under reduced pressure. Excess ethyl chloroformate was entrained with benzene to obtain 11 g of ethyl 3-(3-methoxyphenyl)-1,2,5,6-tetrahydro-1-pyridine-carboxylate.

Workup

  1. customwas then evaporated to dryness under reduced pressure

Sources & evidence

ORD record
ord-633c5a16566a4d199b0f7de5efb8980d
Source dataset
uspto-grants-1983_05
Patent number
US04382942

Reaction notes

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