反应详情

A mixture of 5 g of 3-(3-methoxyphenyl)-1,2,5,6-tetrahydropyridine hydrochloride, 100 ml of acetone, 7 g of sodium carbonate and 3.5 ml of phenethyl bromide was refluxed for 16 hours and was filtered. The filtrate was evaporated to dryness and the residue was chromatographed over silica gel. The elution with a 7-3 cyclohexane-ethyl acetate mixture yielded 6.2 g of 3-(3-methoxyphenyl)-1-phenethyl-1,2,5,6-tetrahydropyridine.

1. temperaturewas refluxed for 16 hours
2. filtrationwas filtered
3. customThe filtrate was evaporated to dryness
4. customthe residue was chromatographed over silica gel
5. washThe elution with a 7-3 cyclohexane-ethyl acetate mixture