Dimethylformamide → HCID 20502640, compound

Participants

Reaction Steps

A mixture of 5 g of the product of Step B, 200 ml of dimethylformamide and 4.3 g of lithium thiomethylate was refluxed for 3 hours and the mixture was cooled and poured into iced water. The mixture was extracted with ethyl acetate and the organic phase was washed with water, dried and evaporated to dryness under reduced pressure. The residue was chromatographed over silica gel and was eluted with a 95-5 chloroform-methanol mixture to obtain 5 g of 1-[{3-(3-hydroxyphenyl)-1,2,5,6-tetrahydropyridin-1-yl}-methyl]-benzenemethanol.

Provenance & Evidence