4-Nitrobenzoyl chloride → HCID 12799174, compound

Participants

Reaction Steps

A mixture of 4.15 g. (0.01 mole) 7-[3-(4-aminopiperidino)-propoxy]-2,3-dihydrocyclopenta[c][1]benzopyran-4(1H)-one dihydrochloride, 2.5 g. sodium bicarbonate and 60 ml. dichloromethane is mixed, while cooling with ice, with a solution of 1.86 g. (0.01 mole) 4-nitrobenzoyl chloride in 20 ml. dichloromethane. The reaction mixture is stirred for 14 hours at ambient temperature, filtered and the precipitate washed with water and dichloromethane and purified by chromatography on silica gel (elution agent dichloromethane:methanol, 9:1 v/v). There are obtained 2.5 g. (51% of theory) of the desired compound; m.p. 212°-213° C.

Provenance & Evidence