Pyridine → HCID 20502717, compound

Participants

Reaction Steps

1.22 g of pyridine are added to 28 g of 7-fluoro-4-hydroxymethyl-2H-1-benzopyrane in 50 ml of diethylether. The mixture is cooled to 5° and 2 g of thionylchloride in 10 ml diethylether slowly added dropwise. The reaction is continued for 30 minutes at 5°-10° and 2 hours at room temperature. The resulting mixture is poured onto ice-water, the organic phase separated and the aqueous phase extracted with a further 20 ml of diethyl ether. The combined ether solutions are dried over MgSO4 and concentrated by evaporation.

Provenance & Evidence