Methylamine → HCID 20502718, compound

Participants

Reaction Steps

500 ml of 33% ethanolic methylamine are added dropwise under ice-water cooling to 105 g 6-chloro-4-chloromethyl-2H-1-benzopyrane. Reaction is continued for 8 hours at room temperature, the mixture concentrated by evaporation and the residue taken up in dichloromethane. The mixture is washed with 500 ml each of 1 N NaOH and water, dried over MgSO4 and concentrated by evaporation. Distillation of the residue yields the title product b.p. 116°-120°/13.3 pascal.

Provenance & Evidence