HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-1-(3-fluoro-4-methoxyphenyl)ethan-1-ol → N-[2-(4-(2-Hydroxyethoxy)phenyl)-1-methylethyl]-2-hydroxy-2-(3-fluoro-4-methoxyphenyl)-ethanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-1-(3-fluoro-4-methoxyphenyl)ethan-1-ol | HCID 13079645 | — |
| Reactant | 1-(4-(2-Hydroxyethoxy)phenyl)propan-2-one | HCID 14578857 | — |
| Product | N-[2-(4-(2-Hydroxyethoxy)phenyl)-1-methylethyl]-2-hydroxy-2-(3-fluoro-4-methoxyphenyl)-ethanamine | HCID 13079630 | — |
Reaction Steps
The compound was prepared as in Example 7, from 1-[4-(2-hydroxyethoxy)phenyl]propan-2-one (3.9 g) and 2-hydroxy-2-(3-fluoro-4-methoxyphenyl)-ethanamine (3.75 g) and crystallised from ether-hexane, mp 112°-115° C. as a 82:18 mixture of diastereoisomers.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04382958 |
| Source dataset | uspto-grants-1983_05 |
| ORD ID | ord-5a378f751bc14d48bcc6612a7b3e0387 |
| Source note | uspto-grants-1983_05 |