HCID 54171553, compound → HCID 13079632, compound

Participants

Reaction Steps

To a solution of N-[2-(4-(3-carbomethoxyprop-2-eneoxy)phenyl)-1-methylethyl]-2-hydroxy-2-(3-trifluoromethylphenyl)ethanamine (1.5 g) in absolute ethanol (50 ml) was added 10% Pd/C (200 mg) and the mixture hydrogenated at ambient temperature and atmospheric pressure until hydrogen uptake had ceased,(approximately 30 minutes). The mixture was filtered and the ethanol evaporated to leave N-[2-(4-(3-carbomethoxypropoxy)phenyl)-1-methylethyl]-2-hydroxy-2-(3-trifluoromethylphenyl)ethanamine as a light yellow oil which crystallised from hexane (1,0 g) m.p. 50°-60°.

Provenance & Evidence