Propionic Acid → HCID 13136981, compound

HRID 851222Notes

Reaction equation

HRID 851222 reaction equation
[CH2:1]([NH:3][CH:4]([CH3:23])[CH2:5][N:6]1[CH2:11][CH2:10][C:9]2[C:12]3[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][C:13]=3[O:14][C:15](=[O:16])[C:8]=2[CH2:7]1)[CH3:2].[BH4-].[Na+].[C:26](O)(=O)[CH2:27][CH3:28]>>[CH2:1]([N:3]([CH2:26][CH2:27][CH3:28])[CH:4]([CH3:23])[CH2:5][N:6]1[CH2:11][CH2:10][C:9]2[C:12]3[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][C:13]=3[O:14][C:15](=[O:16])[C:8]=2[CH2:7]1)[CH3:2]

Participants

4

Reactant 3

HCID 1032Propionic AcidHCID 4311764Sodium borohydrideHCID 13136975HCID 13136975, compound

Product 1

HCID 13136981HCID 13136981, compound

Procedure

Prepared by the method described for Example 59 from 3-[2-(ethylamino)propyl]-1,2,3,4-tetrahydro-8-methoxy-5H-[1]benzopyrano[3,4-c]pyridin-5-one (3.0 g, 0.009 moles), propionic acid (20 ml), and sodium borohydride (2.0 g, 0.053 moles). The free base is obtained crystalline. Recrystallization from acetonitrile gave the product (2.0 g), mp 100°-101° C.

Workup

  1. customPrepared by the method
  2. customThe free base is obtained crystalline
  3. customRecrystallization from acetonitrile

Sources & evidence

ORD record
ord-efebbaef5a5a43c8859e3c4bdc5d6a63
Source dataset
uspto-grants-1983_05
Patent number
US04382939

Reaction notes

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