Acetic Acid → HCID 13136990, compound

HRID 851224Notes

Reaction equation

HRID 851224 reaction equation
[CH2:1]([NH:3][CH:4]([CH3:22])[CH2:5][N:6]1[CH2:11][CH2:10][C:9]2[C:12]3[CH:20]=[CH:19][C:18]([CH3:21])=[CH:17][C:13]=3[O:14][C:15](=[O:16])[C:8]=2[CH2:7]1)[CH3:2].[BH4-].[Na+].[C:25](O)(=O)[CH3:26]>>[CH2:1]([N:3]([CH2:25][CH3:26])[CH:4]([CH3:22])[CH2:5][N:6]1[CH2:11][CH2:10][C:9]2[C:12]3[CH:20]=[CH:19][C:18]([CH3:21])=[CH:17][C:13]=3[O:14][C:15](=[O:16])[C:8]=2[CH2:7]1)[CH3:2]

Participants

4

Reactant 3

HCID 176Acetic AcidHCID 4311764Sodium borohydrideHCID 13136973HCID 13136973, compound

Product 1

HCID 13136990HCID 13136990, compound

Procedure

Prepared by the method described for Example 59 from 3-[2-(ethylamino)propyl]-1,2,3,4-tetrahydro-8-methyl-5H-[1]benzopyrano[3,4-c]pyridin-5-one (3.0 g, 0.010 moles), glacial acetic acid (20 ml), and sodium borohydride (2.3 g, 0.061 moles). Recrystallization from ethanol gave the product (2.0 g) as the dihydrochloride, mp 254° C. (dec.).

Workup

  1. customPrepared by the method
  2. customRecrystallization from ethanol

Sources & evidence

ORD record
ord-975b5a293e5e42bca5e471c2d5492d59
Source dataset
uspto-grants-1983_05
Patent number
US04382939

Reaction notes

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