Isobutyric Acid → HCID 13137001, compound

Participants

Reaction Steps

Prepared by the method described in Example 73 from 3-[2-(ethylamino)propyl]-1,2,3,4-tetrahydro-8,9-dimethoxy-5H-[1]benzopyrano[3,4-c]pyridin-5-one dihydrochloride (6.7 g, 0.016 moles), sodium acetate (2.6 g, 0.032 moles), sodium borohydride (3.3 g, 0.087 moles), and 2-methylpropionic acid (28.5 g, 0.32 moles) instead of acetic acid. Several recrystallizations from diisopropyl ether yielded the final product as the free base (1.4 g), mp 108°-111° C.

Provenance & Evidence