Diethyl Sulfate → HCID 13137009, compound

Participants

Reaction Steps

Prepared by the method described in Example 37 from 3-[2-(diethylamino)propyl]-1,2,3,4-tetrahydro-8,9-dihydroxy-5H-[1]benzopyrano[3,4-c]pyridin-5-one dihydrobromide (17.0 g, 0.034 moles), potassium carbonate (27.6 g, 0.20 moles), and diethyl sulfate (20.0 g, 0.13 moles). The crude free base product is converted to the dihydrochloride in absolute ethanol. A second recrystallization from ethanol yielded the final product (1.8 g), mp 148°-152° C.

Provenance & Evidence