Methanol → HCID 86738867, compound

Participants

Reaction Conditions

Reaction Steps

1.5 g of air-dried ion exchanger SPC 118 (H-form of a cation exchanger, strongly acid, macroporous), 16 g (0.5 mole) of methanol and 58.5 g (0.55 mole) of orthoformic acid trimethyl ester were added to a solution of 101.5 g (0.5 mole) of 3-bromo-4-fluorobenzaldehyde in 200 ml of toluene, the mixture was stirred for a further 1 hour without a bath and was then warmed at 50° C. for 2 hours. The reaction mixture was cooled, filtered to remove the ion exchanger and washed with 200 ml of 5% strength potassium carbonate solution. The solvent was then stripped off and the residue was distilled in vacuo. 118 g (95% of theory) of 3-bromo-4-fluorobenzaldehyde dimethyl acetate were obtained in this way, in the form of a colorless liquid with a boiling point of 68° C./0.1 mm Hg.

Provenance & Evidence