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Potassium Carbonate → 1,2,5,6-Tetrahydro-1-(4,4-diphenyl-3-butenyl)-3-pyridinecarboxylic acid methyl ester hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Norarecoline Hydrochloride | HCID 201540 | — |
| 反応物 | 4,4-Diphenyl-3-butenyl bromide | HCID 10401774 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | 1,2,5,6-Tetrahydro-1-(4,4-diphenyl-3-butenyl)-3-pyridinecarboxylic acid methyl ester hydrochloride | HCID 70483543 | — |
反応手順
A mixture of 5.0 g. (0.0282 mole) of 1,2,5,6-tetrahydro-3-pyridinecarboxylic acid methyl ester, hydrochloride, 8.08 g. (0.282 mole) of 4,4-diphenyl-3-butenyl bromide and 10 g. of crushed potassium carbonate was refluxed in 200 ml. of acetone for 15 hours. The reaction mixture was evaporated, extracted into ethyl acetate from water, dried, evaporated and chromatographed on silica (dry column) eluted with hexane/hexane:ethyl acetate to give 1,2,5,6-tetrahydro-1-(4,4-diphenyl-3-butenyl)-3-pyridinecarboxylic acid methyl ester hydrochloride.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04383999 |
| 出典データセット | uspto-grants-1983_05 |
| ORD ID | ord-773d2e2948554465a5cd2519b28d69e4 |
| 出典メモ | uspto-grants-1983_05 |