Water → HCID 13385964, compound

Participants

Reaction Steps

A solution comprising 3 grams of 2-methylthio-4-chloro-5 ethoxy pyrimidine in 30 milliliters of benzene was treated with 1 gram of sodium amide and 1.5 ml of propargyl alcohol. The reaction mixture was refluxed with stirring for 5 hours. Upon cooling, the unreacted sodium amide was decomposed with water, the benzene layer separated and the solvent evaporated under reduced pressure. Crystallization of the residue from ethanol yielded 2.8 grams of 2-methylthio-4-propargyloxy-5-ethoxy pyrimidine having a melting point ranging from 84°-85° C.

Provenance & Evidence