2-Methyl-2-butanol → 2,6-Dimethyl-4-(2-methyl-3-(4-(2-methylbutan-2-yl)phenyl)propyl)morpholine

HRID 851318Notes

Reaction equation

HRID 851318 reaction equation
[CH3:1][CH:2]([CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH2:3][N:4]1[CH2:9][CH:8]([CH3:10])[O:7][CH:6]([CH3:11])[CH2:5]1.[CH3:19][C:20](O)([CH2:22][CH3:23])[CH3:21]>>[C:20]([C:16]1[CH:15]=[CH:14][C:13]([CH2:12][CH:2]([CH3:1])[CH2:3][N:4]2[CH2:5][CH:6]([CH3:11])[O:7][CH:8]([CH3:10])[CH2:9]2)=[CH:18][CH:17]=1)([CH2:22][CH3:23])([CH3:21])[CH3:19]

Participants

3

Reactant 2

HCID 64052-Methyl-2-butanolHCID 10467168Amorolfine Impurity 13(Isomer mixture)

Product 1

HCID 21682,6-Dimethyl-4-(2-methyl-3-(4-(2-methylbutan-2-yl)phenyl)propyl)morpholine

Procedure

4-[3-(p-tert.amyl-phenyl)-2-methyl-propyl]-2,6-dimethyl-morpholine, b.p. 136°-138° C./0.04 Torr is prepared from 4-(2-methyl-3-phenyl-propyl)-2,6-dimethyl-morpholine and 2-methyl-2-butanol.

Sources & evidence

ORD record
ord-94e1b219bd41468ab14e52638b596141
Source dataset
uspto-grants-1983_05
Patent number
US04384116

Reaction notes

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