Methanol → 1-(2-Methyl-3-phenyl-propyl)-piperidine

Participants

Reaction Steps

A mixture of 1000 g of α-methyl-cinnamaldehyde, 10 liters of methanol and 640 g of piperidine are placed under a nitrogen atmosphere and 50 g of palladium/carbon are added thereto. The mixture is then hydrogenated while cooling with water to 30° C. internal temperature. Hydrogenation continued until the hydrogen uptake has been completed. The catalyst was filtered off and the methanol was distilled under vacuum. Distillation of the crude produce yielded pure 1-(2-methyl-3-phenyl-propyl)-piperidine, b.p. 92° C./0.04 Torr.

Provenance & Evidence