反应详情

Finely ground 3-ethoxycarbonyloxybenzoic acid (10.5 g) was added with stirring to concentrated sulphuric acid at 2°. A mixture of concentrated sulphuric acid (10 ml) and 70% nitric acid (4.5 g) was then added dropwise with stirring, keeping the temperature at 5° or below. When addition was complete, the solution was stirred for another 30 minutes and then poured into ice and water (200 ml). The white solid which separated was washed with water and taken up in chloroform. The solution was dried (MgSO4) and concentrated to yield 5-ethoxycarbonyloxy-2-nitrobenzoic acid (9.8 g) with a melting point of 126°-130°.

1. additionwas then added dropwise
2. customat 5° or below
3. additionWhen addition
4. stirringthe solution was stirred for another 30 minutes
5. customThe white solid which separated
6. washwas washed with water
7. dry with materialThe solution was dried (MgSO4)
8. concentrationconcentrated