反应详情

A mixture of (4RS)-1-(tert-butyl-dimethylsilyl)-4-(2-oxoethyl)-2-oxoazetidine (240 mg) and benzyl triphenylphosphoranylidene-acetate (521 mg) in dichloromethane (5 ml) was heated under refluxing for one hour. After removal of the solvent, the residue was chromatographed on silica gel (7 g) eluting with a mixture of dichloromethane and acetone (50:1) to give benzyl 4-[(2RS)-1-(tert-butyl-dimethylsilyl)-4-oxoazetidin-2-yl]but-2-enoate (373 mg) as an oil.

1. temperaturewas heated
2. temperatureunder refluxing for one hour
3. customAfter removal of the solvent
4. customthe residue was chromatographed on silica gel (7 g)
5. washeluting with a mixture of dichloromethane and acetone (50:1)