HCID 70489672, compound → HCID 54191506, compound

Participants

Reaction Steps

A solution of methyl 4-[(2R,3R)-1-methoxalyl-4-oxo-3-phthalimidoazetidin-2-yl]-3-oxobutanoate (68 mg) in methanol (4 ml) was stirred at room temperature for 16 hours and heated at 55°-60° C. for two hours. The resultant solution was evaporated, and the residue was chromatographed on a silica gel plate (developing solvent: 20% acetone in dichloromethane) to afford methyl 3-oxo-4-[(2R,3R)-4-oxo-3-phthalimidoazetidin-2-yl]butanoate (35 mg) as an amorphous solid. Crystallization from a mixture of ethyl acetate and ether gave crystals (26 mg), mp 120°-124° C.

Provenance & Evidence