Hydrochloric Acid → HCID 12940897, compound

Participants

Reaction Conditions

Reaction Steps

4-(4-Chlorophenyl)-2-(4-hydroxyphenyl)-thiazole-5-acetic acid (7.0 g, 0.016 moles) was dissolved in 0.1 N sodium hydroxide (493 ml, 0.372 moles) and cooled to 0° C. Acetic anhydride (1.5 ml, 0.016 moles) was added and the mixture left standing at room temperature for 3 hours. To the solution was added dilute hydrochloric acid and the resulting precipitate was filtered off, washed with a little water, dried and recrystallised from methylethylketone to give 2-(4-acetoxyphenyl)-4-(4-chlorophenyl)thiazole-5-acetic acid as a colourless solid (2.4 gm), m.p. 177°-180° C.

Provenance & Evidence