Sodium Hydroxide → 4-hydroxyfentiazac

HRID 851475Notes

Reaction equation

HRID 851475 reaction equation
C([O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[S:12][C:13]([CH2:23][C:24]([OH:26])=[O:25])=[C:14]([C:16]3[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=3)[N:15]=2)=[CH:7][CH:6]=1)(=O)C.[OH-].[Na+]>>[Cl:22][C:19]1[CH:18]=[CH:17][C:16]([C:14]2[N:15]=[C:11]([C:8]3[CH:7]=[CH:6][C:5]([OH:4])=[CH:10][CH:9]=3)[S:12][C:13]=2[CH2:23][C:24]([OH:26])=[O:25])=[CH:21][CH:20]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 12940897HCID 12940897, compound

Product 1

HCID 1289074-hydroxyfentiazac

Procedure

2-(4-Acetoxyphenyl)-4-(4-chlorophenyl)-thiazole-5-acetic acid is hydrolysed using 2 N sodium hydroxide to give the title compound.

Sources & evidence

ORD record
ord-a2f2dc4ddbc642bda22dd45cb5261f75
Source dataset
uspto-grants-1983_05
Patent number
US04385059

Reaction notes

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