4-Hydroxythiobenzamide → HCID 135672569, compound

HRID 851476Notes

Reaction equation

[CH3:1][O:2][C:3](=[O:16])[CH2:4][CH:5](Br)[C:6](=O)[C:7]1[CH:12]=[CH:11][C:10]([Cl:13])=[CH:9][CH:8]=1.[OH:17][C:18]1[CH:26]=[CH:25][C:21]([C:22]([NH2:24])=[S:23])=[CH:20][CH:19]=1>>[Cl:13][C:10]1[CH:11]=[CH:12][C:7]([C:6]2[N:24]=[C:22]([C:21]3[CH:25]=[CH:26][C:18]([OH:17])=[CH:19][CH:20]=3)[S:23][C:5]=2[CH2:4][C:3]([O:2][CH3:1])=[O:16])=[CH:8][CH:9]=1

Participants

Reactant 2

HCID 27593444-Hydroxythiobenzamide

HCID 12864897HCID 12864897, compound

Product 1

HCID 135672569HCID 135672569, compound

Procedure

By a process analogous to Example 2, methyl-3-bromo-3-(4-chlorobenzoyl)propionate and 4-hydroxy-thiobenzamide are reacted to give methyl 4-(4-chlorophenyl)-2-(4-hydroxyphenyl)thiazole-5-acetate. This compound is hydrolysed using 2 N sodium hydroxide to give the title compound.

Sources & evidence

ORD record: ord-1153c518b64c4f2bb3fd58c17f37949b
Source dataset: uspto-grants-1983_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04385059

Reaction notes

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