HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Trifluoromethyl)phenylglyoxal → N-(2-(4-Carbomethoxyphenyl)ethyl)-2-hydroxy-2-(3-trifluoromethylphenyl) ethanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Trifluoromethyl)phenylglyoxal | HCID 2783284 | — |
| Reactant | Methyl 4-(2-aminoethyl)benzoate | HCID 11183521 | — |
| Product | N-(2-(4-Carbomethoxyphenyl)ethyl)-2-hydroxy-2-(3-trifluoromethylphenyl) ethanamine | HCID 15087214 | — |
Reaction Steps
The title compound was prepared as in Example 1a from 3-trifluoromethylphenyl glyoxal (3.85 g) and 2-(4-carbomethoxyphenyl) ethanamine (3.4 g), and crystallised from hexane m.p. 75-77.5. τ(CDCl3) 7.66 (2H, broad, replaceable by D2O), 5.9-6.5 (6H, m), 6.15 (3H,s), 5.3 (1H,m), 2.75 (2H,d,J=8 Hz), 2.3-2.6 (4H,m), 2.03 (2H,d,J=8 Hz).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04385066 |
| Source dataset | uspto-grants-1983_05 |
| ORD ID | ord-2645174f3d6c4fa9a1cd8fa504fc1552 |
| Source note | uspto-grants-1983_05 |