2-Amino-1-[3-(trifluoromethyl)phenyl]ethan-1-ol → HCID 20501356, compound

Participants

Reaction Steps

The title compound was prepared as in Example 1b from 1-(4-carbomethoxy-2-methoxyphenyl)propan-2-one (3.0 g) and 2-hydroxy-2-(3-trifluoromethylphenyl)ethanamine (2.77 g). The compound crystallised from hexane m.p. 88°-100° as a 70:30 mixture of diastereoisomers. τ(CDCl3) 8.8 (3H,d,J=6 Hz), 6.7-7.7 (5H,m,+2H replaceable by D2O), 6.1 (3H,s), 6.0 (3H,s), 5.2 (1H, m), 2.8 (2H,d,J=8 Hz), 2.2-2.6 (6H,m).

Provenance & Evidence