2-Amino-1-[3-(trifluoromethyl)phenyl]ethan-1-ol → N-[2-(4-Carbomethoxy-3-methylphenyl)-1-methylethyl]-2-hydroxy-2-(3-trifluoromethylphenyl)ethanamine

Participants

Reaction Steps

The title compound was prepared as in Example 1b from 1-(4-carbomethoxy-3-methylphenyl)propan-2-one (2.0 g) and 2-hydroxy-2-(3-trifluoromethylphenyl)ethanamine (2.0 g), the compound crystallised from hexane m.p. 88°-92° as a 41:59 mixture of diastereoisomers. τ(CDCl3) 8.9 (3H,d,J=6 Hz), 7.4 (3H,s), 6.8-7.8 (5H,m,=2H, replaceable by D2O), 6.1 (3H,s), 5.3 (1H,m), 2.9 (2H,m), 2.3-2.6 (4H,m), 2.1 (1H,dd,J=8 Hz, J=2 Hz).

Provenance & Evidence