Sulfuric Acid → HCID 20501407, compound

Participants

Reaction Steps

Into a 300-ml four-necked flask, were charged 27.8 g of 6-methyl-2,4-di-t-butyl-3-hydroxyphenylacetic acid, 150 ml of toluene and 3 ml of concentrated sulfuric acid. The mixture was heated under reflux for about 5 hours under a nitrogen stream. After completion of the reaction, the reaction mixture was neutralized with an aqueous sodium carbonate solution, washed with water, then dehydrated and freed from the solvent under reduced pressure to obtain 21.5 g (97% yield) of pale yellow 2-methyl-4-t-butyl-5-hydroxyphenylacetic acid which was recrystallized from a chloroform-hexane mixture to yield white crystals melting at 132° to 134° C.

Provenance & Evidence